ESPE Yearbook of Paediatric Endocrinology

To read the full abstract: The FASEB Journal 2019;33:12680–12695.These authors conditionally deleted the IGF1 receptor gene (IGF1R) in tenocytes using a tamoxifen-inducible Cre-recombinase system and then stimulated plantaris tendon growth in adult mice via mechanical loading. Mice that lacked IGF1R in their tenocytes showed reduced cell proliferation and tendon growth in response to mechanical loading. These studies indicate that IGF1 sign...